منابع مشابه
Finally, a transgenic light chain amyloidosis mouse model.
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We here report for the first time on the chemical characteristics of proteoglycans associated with mouse splenic reactive AA amyloid. Amyloid was induced in CBA/J mice by two different procedures; conventional casein treatment and by employing Freund's complete adjuvant, accelerated by Trypan Blue. Pulse-labelling was employed at distinct stages during amyloid development, followed by [35S]prot...
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AA amyloidosis is a systemic disease that develops secondary to chronic inflammatory diseases Macrophages are often found in the vicinity of amyloid deposits and considered to play a role in both formation and degradation of amyloid fibrils. In spleen reside at least three types of macrophages, red pulp macrophages (RPM), marginal zone macrophages (MZM), metallophilic marginal zone macrophages ...
متن کاملBIOLOGICAL SCIENCES: Medical Sciences Pathogenetic mechanisms of AA amyloidosis Short title: Pathogenesis of AA amyloidosis
a Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK; b Centre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, UK; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy; d Centre for Neuroendocrinology, Division of Medicine, University Colle...
متن کاملTransmission of systemic AA amyloidosis in animals.
Amyloidoses are a group of protein-misfolding disorders that are characterized by the deposition of amyloid fibrils in organs and/or tissues. In reactive amyloid A (AA) amyloidosis, serum AA (SAA) protein forms deposits in mice, domestic and wild animals, and humans that experience chronic inflammation. AA amyloid fibrils are abnormal β-sheet-rich forms of the serum precursor SAA, with conforma...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1999
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65378-3